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G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells

Atrazine, one of the most common pesticide contaminants, has been shown to
up-regulate aromatase activity in certain estrogen-sensitive tumors without binding or activating
the estrogen receptor (ER). Recent investigations have demonstrated that the orphan G-protein–
coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates rapid actions
of 17β-estradiol and environmental estrogens.

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