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GPER activates Notch signaling in breast cancer cells

GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs) Introduction: Estrogens regulate critical signaling pathways involved in the control of cell proliferation and differentiation in reproductive and non-reproductive tissues Scarica l’articolo

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G-Protein–Coupled Receptor 30 and Estrogen Receptor-α

G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells OBJECTIVES: Given the ability of atrazine to exert estrogen-like activity in cancer cells, we evaluated the potential of atrazine to signal through GPR30 in stimulating biological responses in cancer cells Scarica …

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A calixpyrrole derivative acts as an antagonist to GPER

A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models INTRODUCTION: Breast cancer is the most frequent malignancy in women, and mortality of affected individuals is mainly caused by the development of metastatic processes (Siegel et al., 2012), whichis driven at least in part …

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Effects of Atrazine on Estrogen Receptor

Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts Objectives: We aimed to evaluate the potential of atrazine to trigger GPER-mediated signaling in cancer cells and cancer-associated fibroblasts Scarica l’articolo

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GPER Mediates Activation

GPER Mediates Activation of HIF1a/VEGF Signaling by Estrogens Introduction: Breast cancer is the most frequently diagnosed malignancy in women in the United States and the leading cause of cancerrelated death in women worldwide Scarica l’Articolo

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Breast Cancer and Venous Disease

Breast Cancer and Venous Disease: A Retrospective Cohort Study Breast cancer (BC) and chronic venous disease (CVD) are in some way related to hormonal effects, and often the clinical manifestations of CVD intersect with the clinical course of BC. This article describes the correlations between these clinical conditions. Scarica l’Articolo

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miR-221 stimulates breast cancer cells and
cancer-associated fibroblasts

miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling Background: MicroRNA (miRNAs) are non-coding small RNA molecules that regulate gene expression by inhibiting the translation of target mRNAs. Among several dysregulated miRNAs in human cancer, the up-regulation of miR-221 has been associated with …

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