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Niacin activates the G protein estrogen receptor

Niacin activates the G protein estrogen receptor (GPER)-mediated signalling

G protein-coupled receptors (GPCRs) are cell-surface proteins involved in multiple pathophysiological responses including cancer. Increasing evidence has demonstrated that theG protein-coupled estrogen receptor, named GPER/GPR30mediates diverse biological effects induced by a wide number of compounds like estrogens, anti-estrogens and environmental contaminants in normal and malignant cells. GPER mediates rapid events that activate diverse transduction pathways leading to a characteristic gene signature involved in important biological functions

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